Tau Protein and Alzheimer's

Alzheimer' s disease and Tau protein

Propagation of tau protein in the brain of Alzheimer's disease sufferers Scientists at the Karolinska Institutet have recently presented a clinical trial in Molecular Psychiatry to measure how tau protein deposition spreads in the course of Alzheimer's. The results are based on the results of the research. The results show that the extent of the reservoir and the rate at which it spreads varies from one person to another and that large quantities of dew in the brains can be associated with an Episodic Mnosis.

At a very early stage of Alzheimer's there is an build-up of dew in the cerebral tissue, the negative effect of which on cellular functions leads to defective memories. In the present trial, Professor Agneta Nordberg from the Department of Neurobiology, Nursing Science and Society at the Karolinska Institute and her PhD candidate Konstantinos Chiotis and the remainder of her research group measured the proliferation of tau deposition and the Alzheimer' s related amoyloid platelet in the brains and recorded the energetic exchange of cerebral cytes.

Then they investigated how these three factors have evolved over the course of the illness. "There was an interna-tional dew propagation measurement competition and we were probably there first," says Professor Nordberg. "No earlier accounts of how dew depositions develop in the illness after 17 month. The results can help to understand tau build-up in Alzheimer's and support current research to quantitatively assess the effect of tau vaccine and allow early diagnosis".

It enrolled 16 Alzheimer' s at various levels from the storage facility of Karolinska Hospital in Huddinge. A number of neurologic remembrance assays were administered to the patient and a CT scan was performed every 17 months. Whereas all 16 subjects had ample amounts of amoyloid plasma in their brains, the extent and rate of propagation of their tau sediments varied significantly between subjects.

"â??We also saw a clear, immediate link between the magnitude of the deposition and the impact on epoxy memory,â Professor Nordberg concludes. "That could account for the different rates of progression of the illness from person to person. However, dew doesn't seem to have much effect on general memories, which are more related to cerebral metabolism."

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